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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

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Related Experiment Video

Updated: Jun 22, 2026

Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation
08:22

Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation

Published on: January 22, 2020

[In vitro capacitation].

C Travert1, S Carreau, I Galeraud-Denis

  • 1UPRES EA 2608-USC INRA, université de Caen, esplanade de la Paix, 14032 Caen cedex, France.

Gynecologie, Obstetrique & Fertilite
|May 30, 2009
PubMed
Summary
This summary is machine-generated.

Sperm capacitation involves significant lipid changes in the sperm membrane, including cholesterol efflux and reorganization, which are crucial for fertilization. These modifications, alongside signaling pathway activation, enable sperm to fertilize an egg.

More Related Videos

Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging
19:26

Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging

Published on: May 24, 2013

Related Experiment Videos

Last Updated: Jun 22, 2026

Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation
08:22

Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation

Published on: January 22, 2020

Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging
19:26

Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging

Published on: May 24, 2013

Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Biochemistry

Context:

  • Sperm capacitation is essential for mammalian fertilization.
  • Lipids are critical for sperm plasma membrane structure and function.
  • Changes in lipid and protein organization occur during capacitation.

Purpose:

  • To elucidate the role of lipid modifications during sperm capacitation.
  • To understand the signaling pathways involved in sperm capacitation.
  • To investigate the contribution of reactive oxygen species (ROS) to capacitation.

Summary:

  • Capacitation involves significant lipid alterations in sperm membranes, including cholesterol efflux and redistribution, particularly in the apical head region.
  • Phospholipid reorganization and activation of scramblase are key events, leading to the formation of lipid rafts.
  • Signaling pathways like AMPc/PKA, ERK, PI3K/Akt, and phosphotyrosine kinases are activated, resulting in protein phosphorylation and are modulated by ROS.

Impact:

  • Provides insights into the molecular mechanisms of sperm capacitation.
  • Highlights the importance of lipid dynamics in male fertility.
  • Identifies potential targets for reproductive technologies and therapies.