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Lobarialides A-C, antifungal triterpenoids from the lichen Lobaria kurokawae
Xiao-Ning Wang1, Hai-Juan Zhang, Dong-Mei Ren
1Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, P. R. China.
Abstract:
Three novel fernane-type triterpenoids, lobarialides A-C (1-3, resp.), together with two known ones were isolated by antifungal bioassay-guided fractionation of the lichen Lobaria kurokawae. Their structures including configurations were established on the basis of extensive spectroscopic analyses, and that of 1 was confirmed by a single-crystal X-ray diffraction analysis. Antifungal tests of the five triterpenoids showed that the activity increased with the increment of the number of COO groups.
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