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Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
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Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
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Updated: Jun 22, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Nutrigenomics/Nutrigenetics.

Nicoleta Mitroi1, Maria Moţa

  • 1Clinical County Emergency Hospital Craiova, Clinic of Diabetes Nutrition and Metabolic Diseases.

Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Proper nutrition is crucial for health, requiring specific nutrient quantities. Both diet and genetics significantly influence human development and disease, necessitating integrated study approaches.

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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Last Updated: Jun 22, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Area of Science:

  • Nutritional Science
  • Genetics
  • Public Health

Background:

  • Historical understanding of nutrition's role in health since Hippocrates.
  • Modern science emphasizes specific nutrient quantities for optimal health.
  • Emergence of dietetic recommendations and nutritional epidemiology.

Purpose of the Study:

  • To highlight the dual influence of nutrition and genetics on health.
  • To underscore the importance of studying environmental and genetic factors interactively.
  • To address limitations in current research focusing on single factors.

Main Methods:

  • Review of historical and modern scientific understanding.
  • Discussion of nutritional epidemiology and dietetic recommendations.
  • Emphasis on the need for integrated experimental approaches.

Main Results:

  • Nutrition is essential for health, with specific quantities of nutrients being critical.
  • Nutrient-gene interactions can influence health outcomes, potentially leading to disease.
  • Human development is a complex interplay of environmental factors and heredity.

Conclusions:

  • A holistic approach considering both diet and genetics is vital for maintaining health.
  • Future research should focus on simultaneous investigation of environmental and genetic influences.
  • Understanding these interactions is key to preventing diet-related diseases.