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Updated: Jun 22, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Serial changes in oxidized low-density lipoprotein associated with culprit vessel in ST-elevation myocardial

Patrícia Napoleão1, Mafalda Selas, Alexandra Toste

  • 1Centro de Biologia Ambiental, Universidade de Lisboa, Lisboa, Portugal. pnapoleao@itn.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|June 2, 2009
PubMed

Insights

Oxidized LDL (oxLDL) is elevated in acute myocardial infarction (AMI) patients, decreasing during recovery. Higher oxLDL correlates with more severe coronary artery disease, suggesting its potential as an AMI marker.

Area of Science:

  • Cardiology
  • Biochemistry
  • Biomarker Discovery

Background:

  • Oxidized low-density lipoprotein (oxLDL) plays a role in atherosclerosis.
  • Acute myocardial infarction (AMI) is a critical cardiovascular event.
  • Understanding biomarkers for AMI progression is crucial.

Purpose of the Study:

  • To investigate oxLDL variations in AMI patients during acute and recovery phases.
  • To explore the relationship between oxLDL levels and coronary artery disease severity.
  • To assess oxLDL as a potential marker for AMI evolution.

Main Methods:

  • Plasma oxLDL concentrations were measured using ELISA.
  • A cohort of 50 AMI patients and 25 healthy controls were studied.
  • AMI patients were assessed at admission, and 2 and 40 days post-intervention.

Main Results:

  • oxLDL levels were significantly higher in AMI patients during the acute phase compared to controls.
  • oxLDL concentrations decreased progressively during the recovery period.
  • Lower oxLDL levels were observed in patients with left circumflex artery (LCX) lesions compared to left anterior descending (LAD) or right coronary artery (RCA) lesions.

Conclusions:

  • Elevated oxLDL is associated with AMI and correlates with coronary artery disease severity.
  • oxLDL levels decrease during recovery from AMI.
  • oxLDL shows promise as a biomarker for assessing AMI progression and prognosis.

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