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Updated: Jun 22, 2026
08:40
Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
Burns as a model of SIRS
1Food and Veterinary Administration, Agri-Food and Veterinary Authority of Singapore, 5 Maxwell Road, #02-03, Tower Block, MND Complex, Singapore 069110. punam_dahiya@ava.gov.sg
Frontiers in Bioscience (Landmark Edition)
|June 2, 2009
Summary
Severe burns trigger systemic inflammatory response syndrome (SIRS), leading to organ damage. This review covers experimental burn models and the role of inflammatory mediators in SIRS and multiple organ dysfunction syndrome (MODS).
Area of Science:
- Burn research
- Inflammation and immunology
- Experimental pathology
Background:
- Thermal injury from burns is a frequent clinical issue.
- Excessive systemic inflammatory response syndrome (SIRS) post-burns causes distant organ damage and multiple organ dysfunction syndrome (MODS).
- In vivo burn models have advanced understanding of thermal injury's physiological and immunological effects.
Purpose of the Study:
- To review experimental animal models of burns and associated SIRS.
- To explore the role of inflammatory mediators in burn pathogenesis and resultant MODS.
Main Methods:
- Overview of various experimental animal models of burns (rodents and large animals).
- Analysis of established research on inflammatory mediators (TNF-alpha, IL-1beta, IL-6, IL-2, substance P) in burn injury.
Main Results:
- Experimental models have elucidated the critical role of specific inflammatory mediators in burn-induced systemic organ damage.
- These mediators are key players in the pathogenesis of both SIRS and MODS following thermal injury.
Conclusions:
- Understanding burn pathogenesis and SIRS/MODS requires robust experimental models.
- Targeting inflammatory mediators presents a potential therapeutic strategy for severe burn management.
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