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Related Experiment Video

Updated: Jun 22, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Thyroid fine-needle aspiration biopsy: variability in reporting.

Carol M Lewis1, Kuo-Ping Chang, Martha Pitman

  • 1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.

Thyroid : Official Journal of the American Thyroid Association
|June 3, 2009
PubMed
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Thyroid fine-needle aspiration biopsy (FNAB) statistics vary widely due to reporting discrepancies. Standardizing these calculations is crucial for accurately assessing FNAB

Area of Science:

  • Endocrinology
  • Cytopathology
  • Surgical Oncology

Background:

  • Thyroid nodules are common, but thyroid cancer is rare, necessitating accurate screening tools.
  • Fine-needle aspiration biopsy (FNAB) is a key diagnostic method for thyroid nodules.
  • Discrepancies in reporting FNAB statistics hinder accurate clinical utility assessment.

Purpose of the Study:

  • To identify and evaluate sources of statistical discrepancies in thyroid FNAB reporting.
  • To re-calculate key performance metrics for thyroid FNAB based on standardized methods.

Main Methods:

  • Analysis of published thyroid FNAB series with >200 cases and available histological data.
  • Recalculation of sensitivity, specificity, accuracy, predictive values, and error rates.

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Published on: May 23, 2015

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Last Updated: Jun 22, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules
06:03

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules

Published on: May 23, 2015

  • Statistical comparison of reported versus recalculated metrics.

    • Main Results:

    • Significant differences were observed in reported versus recalculated specificity and false-positive rates.
    • Recalculated specificity decreased from 81% to 62%, while false-positive rates increased from 10% to 38%.
    • Variability in defining positive FNAB results significantly impacts reported statistics.

    Conclusions:

    • Thyroid FNAB is the preferred screening tool for thyroid nodules.
    • Standardized statistical reporting is essential for a clear understanding of thyroid FNAB's diagnostic performance.
    • Addressing reporting inconsistencies will improve clinical decision-making for thyroid nodule management.