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Biofilms in chronic rhinosinusitis: a review
Michael Cohen1, Jennifer Kofonow, Jayakar V Nayak
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA. cohenn@uphs.upenn.edu
American Journal of Rhinology & Allergy
|June 4, 2009
Summary
Bacterial biofilms, communities of bacteria in a protective matrix, are linked to chronic rhinosinusitis (CRS). Research suggests these biofilms contribute to CRS progression in some patients, necessitating further therapeutic development.
Area of Science:
- Microbiology
- Otolaryngology
- Infectious Diseases
Background:
- Bacterial biofilms are structured communities of bacteria embedded in an exopolymeric matrix, adhering to surfaces.
- This matrix protects bacteria from host defenses and antibiotics, facilitating recurrent infections.
- Biofilms are hypothesized to play a role in the development and persistence of chronic rhinosinusitis (CRS).
Purpose of the Study:
- To review seminal research supporting the hypothesis that bacterial biofilms contribute to chronic rhinosinusitis.
- To consolidate evidence on the presence and impact of biofilms in CRS patients.
Main Methods:
- This work is a review of existing literature.
- Key studies investigating bacterial biofilms in the context of CRS were summarized.
Main Results:
- Imaging studies confirm the presence of biofilms in the sinonasal mucosa of CRS patients.
- Studies correlate biofilm presence with poorer clinical outcomes in CRS.
- Initial therapeutic interventions targeting biofilms in CRS have yielded inconsistent results.
Conclusions:
- Bacterial biofilms are implicated in the progression of chronic rhinosinusitis in a portion of patients.
- Further research and therapeutic strategies are required to effectively manage biofilm-associated CRS.
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