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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...

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Updated: Jun 22, 2026

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
09:51

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Published on: April 13, 2016

ICP-MS-based strategies for protein quantification.

Meng Wang1, Wei-Yue Feng, Yu-Liang Zhao

  • 1Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, 100049 Beijing, PR China.

Mass Spectrometry Reviews
|June 4, 2009
PubMed
Summary
This summary is machine-generated.

Proteomics now requires protein quantification for understanding biological functions. Inductively coupled plasma-mass spectrometry (ICP-MS) offers a promising new method for accurate protein quantification in life sciences research.

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Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification

Published on: August 17, 2015

Area of Science:

  • Life Sciences
  • Biochemistry
  • Analytical Chemistry

Background:

  • The post-genomics era emphasizes the need for quantitative proteomics.
  • Understanding biological functions requires both protein identification and quantification.
  • Current quantitative proteomics primarily uses isotope labeling with molecular mass spectrometry.

Purpose of the Study:

  • To review recent advances in inductively coupled plasma-mass spectrometry (ICP-MS) for quantitative proteomics.
  • To highlight ICP-MS as a complementary technique to existing mass spectrometry methods.
  • To discuss the potential of ICP-MS for absolute protein quantification.

Main Methods:

  • Review of recent literature on ICP-MS applications in proteomics.
  • Selective discussion of ICP-MS-based techniques for protein quantification.
  • Comparison with established methods like electrospray MS and MALDI MS.

Main Results:

  • ICP-MS has emerged as a significant advancement in quantitative proteomics.
  • ICP-MS shows particular promise for absolute protein quantification.
  • This technique is a valuable complement to traditional mass spectrometry approaches.

Conclusions:

  • ICP-MS-based techniques are maturing rapidly in the field of quantitative proteomics.
  • ICP-MS is expected to become a key methodology in future proteomics research.
  • The adoption of ICP-MS will enhance the precision and scope of proteomic analyses.