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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

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Related Experiment Video

Updated: Jun 22, 2026

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
07:32

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

Cellular targeting for cochlear gene therapy.

Allen F Ryan, Lina M Mullen, Joni K Doherty

    Advances in Oto-Rhino-Laryngology
    |June 5, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Gene therapy offers potential for inner ear disorders by targeting specific genes. Precise spatial and temporal delivery using cell-specific and conditional promoters is key for effective treatment of inherited hearing loss.

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    Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
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    Related Experiment Videos

    Last Updated: Jun 22, 2026

    Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
    07:32

    Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

    Published on: March 16, 2015

    Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
    03:52

    Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

    Published on: March 2, 2018

    Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
    09:34

    Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

    Published on: May 25, 2018

    Area of Science:

    • Otolaryngology
    • Genetics
    • Molecular Biology

    Background:

    • Inherited hearing loss is increasingly linked to specific genes and mutations.
    • The inner ear's complexity requires precise targeting for effective gene therapy.
    • Current gene therapy approaches face challenges in cell and time-specific delivery.

    Purpose of the Study:

    • To explore the potential of targeted gene therapy for inner ear disorders.
    • To examine methods for achieving precise spatial and temporal control of gene delivery.
    • To review the application of cell-specific and conditional promoters in inner ear gene therapy.

    Main Methods:

    • Review of genetic links to inherited hearing loss.
    • Analysis of inner ear cell types and gene expression timing.
    • Evaluation of cell-specific and conditional promoter technologies.

    Main Results:

    • Identification of numerous genes and mutations associated with hearing loss.
    • Understanding of the critical timing and cell-specific requirements for gene therapy.
    • Potential of promoter technologies to enable targeted gene delivery.

    Conclusions:

    • Gene therapy holds promise for treating inner ear conditions.
    • Targeting gene therapy to specific cells and times is crucial for efficacy.
    • Cell-specific and conditional promoters offer a viable strategy for precise inner ear gene therapy.