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Published on: July 11, 2025
Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii
Jean Duplex Wansi1, Hidayat Hussain, Alain Tadjong Tcho
1Department of Chemistry, University of Douala, Faculty of Science, Douala, Cameroon.
Abstract:
The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and beta-sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1-4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth.
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