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Updated: Jun 22, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infections

Gita Wasan Patel1, Nimish Patel, Asma Lat

  • 1Medical Center of Plano, TX 75075, USA.

Diagnostic Microbiology and Infectious Disease
|June 9, 2009
PubMed

Insights

Intermittent versus extended-infusion piperacillin-tazobactam showed similar patient outcomes for Gram-negative infections. Mortality and hospital stay were comparable between the two administration methods, even when considering minimum inhibitory concentration (MIC) values.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Background:

  • Piperacillin-tazobactam is a critical antibiotic for Gram-negative infections.
  • Optimizing antibiotic administration is key to improving patient outcomes.
  • Intermittent and extended infusion are common methods for delivering beta-lactam antibiotics.

Purpose of the Study:

  • To compare the clinical efficacy of intermittent versus extended-infusion piperacillin-tazobactam.
  • To evaluate patient mortality and length of hospital stay based on infusion method.
  • To assess if outcomes differ based on the minimum inhibitory concentration (MIC) of the infecting pathogen.

Main Methods:

  • Retrospective analysis of patients receiving piperacillin-tazobactam for Gram-negative infections.
  • Comparison of mortality rates between intermittent and extended infusion groups.
  • Analysis of length of stay for both treatment groups.
  • Stratification of outcomes by pathogen MIC values.

Main Results:

  • No significant difference in mortality was observed between intermittent and extended-infusion groups.
  • Length of hospital stay was similar for patients receiving either infusion method.
  • Outcomes remained comparable across both groups when stratified by MIC values.

Conclusions:

  • Extended-infusion piperacillin-tazobactam offers similar clinical benefits to intermittent infusion for Gram-negative infections.
  • Infusion method does not appear to significantly impact mortality or length of stay.
  • Piperacillin-tazobactam dosing strategy can be tailored based on clinical context and MIC values.

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