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Related Experiment Video

Updated: Feb 10, 2026

Subjective Refraction Test Using a Smartphone for Vision Screening
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cMET and refractive error progression in children.

Chiea C Khor1, Robert Grignani, Daniel P K Ng

  • 1Genetic Medicine Group, Singapore Institute for Clinical Sciences, Singapore. khor_chiea_chuen@sics.a-star.edu.sg

Ophthalmology
|June 9, 2009
PubMed
Summary
This summary is machine-generated.

Genetic variation in the cMET gene is linked to increased myopia susceptibility and faster refractive error progression in children. This finding highlights the role of cMET in common myopia development and progression.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatric Eye Care

Background:

  • Refractive error, including myopia, is a common vision disorder with complex etiology.
  • Genetic factors are known to play a significant role in refractive error development and progression.

Purpose of the Study:

  • To investigate the association between genetic variations in the cMET gene and refractive error in children.
  • To determine if cMET gene variants influence the rate of change in refractive error over time.

Main Methods:

  • A cohort study design was employed with two sets of children (discovery and confirmatory).
  • Genetic markers within the cMET gene were genotyped in participants.
  • Refractive error and its rate of change over a 3-year period were assessed.

Main Results:

  • A specific cMET variant (+110703 A allele) was associated with increased myopia susceptibility.
  • This cMET variant correlated with a faster rate of refractive error change in both study sets.
  • Children with the variant allele showed significantly faster progression of refractive error compared to those without.

Conclusions:

  • The cMET gene is implicated in the pathogenesis of myopia.
  • Genetic variations in cMET may contribute to the progression of refractive error, irrespective of initial refractive status.
  • These findings underscore the importance of eye growth genes in the development of common myopia.