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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.

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Related Experiment Video

Updated: Jun 22, 2026

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
11:57

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

Epigenetic dysregulation in cognitive disorders.

Johannes Gräff1, Isabelle M Mansuy

  • 1Brain Research Institute, Medical Faculty of the University of Zürich, Zürich, Switzerland.

The European Journal of Neuroscience
|June 11, 2009
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms regulate gene expression and are crucial for brain function. Dysregulation is linked to cognitive disorders, but their dynamic nature offers potential for new treatments.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Epigenetic mechanisms are vital for stable cellular processes like cell identity and dynamic responses to environmental stimuli.
  • These mechanisms play a critical role in complex brain functions.
  • Disruptions in epigenetic regulation and chromatin remodeling are implicated in neurodevelopmental and neurodegenerative disorders, impacting cognitive functions.

Purpose of the Study:

  • To review cognitive disorders associated with epigenetic dysregulation.
  • To explore the potential of epigenetic medicine for treating these disorders.

Main Methods:

  • Literature review of studies on epigenetics and cognitive disorders.
  • Analysis of evidence linking epigenetic dysregulation to diseases like Alzheimer's and Rett syndrome.

Main Results:

  • Epigenetic mechanisms are essential for both stable biological functions and dynamic gene expression changes.
  • Proper control of epigenetic mechanisms and chromatin remodeling is critical for cognitive function.
  • Dysregulation of these mechanisms can lead to severe consequences in neurological disorders.

Conclusions:

  • Epigenetic mechanisms are fundamental to brain function and cognitive processes.
  • Their dynamic and reversible nature presents opportunities for therapeutic interventions.
  • Epigenetic medicine holds promise as a novel treatment strategy for cognitive disorders stemming from epigenetic dysregulation.