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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Integrated Healthcare System01:20

Integrated Healthcare System

An integrated healthcare system (IHS) is a set of organizations that provides for or arranges to provide coordinated and continuous service to a defined population. The IHS takes responsibility for that particular population's health status and outcome, both clinically and fiscally. An integrated healthcare system is a well-organized, well-coordinated, and collaborative network. The integrated delivery system is a network that connects different healthcare providers to deliver organized,...
Tertiary Healthcare System01:21

Tertiary Healthcare System

Specialized care provided over an extended period is called tertiary care. Usually, a primary or secondary care physician will refer a patient to tertiary care. A patient's maximum physical and mental function is restored in tertiary care, which is caused due to the impact of a chronic illness or condition. Tertiary care aims to achieve the highest level of functioning possible while managing chronic illness. For example, a patient who falls and fractures their hip will need secondary care to...

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Establishing an Octopus Ecosystem for Biomedical and Bioengineering Research
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An infrastructure for interconnecting research institutions.

Kenneth H Buetow1

  • 1Center for Bioinformatics and Information Technology, National Cancer Institute, Rockville, MD 20852, USA. buetowk@nih.gov

Drug Discovery Today
|June 11, 2009
PubMed
Summary
This summary is machine-generated.

Personalized medicine offers solutions to pharmaceutical challenges. The cancer Biomedical Informatics Grid (caBIG) program provides essential IT infrastructure for data sharing and collaboration, enabling personalized medicine research.

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Area of Science:

  • Biomedical Informatics
  • Translational Research
  • Personalized Medicine

Background:

  • The pharmaceutical industry faces challenges that personalized medicine aims to address.
  • Implementing personalized medicine requires advanced, interoperable IT infrastructures for data management and collaboration.

Purpose of the Study:

  • To describe how the cancer Biomedical Informatics Grid (caBIG) program facilitates personalized medicine research.
  • To highlight the role of caBIG's technology in enabling data access, sharing, and collaboration.

Main Methods:

  • Review of the technology developed within the National Cancer Institute's caBIG program.
  • Analysis of how caBIG infrastructure supports personalized medicine initiatives in research organizations.

Main Results:

  • caBIG technology is actively enabling research organizations to adopt personalized medicine approaches.
  • The program's infrastructure supports simpler data access, data sharing, and enhanced collaboration.

Conclusions:

  • The caBIG program's IT infrastructure is crucial for advancing personalized medicine.
  • Novel, interoperable IT solutions are key to realizing the full potential of personalized medicine in research.