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Updated: Jun 22, 2026
Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice
Published on: December 2, 2022
Functional state of pulmonary macrophages after partial hepatectomy in mice
V A Shkurupiy1, D D Tsyrendorzhiev, S S Saparbaev
1Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. sck@soramn.ru
Abstract:
Partial hepatectomy leads to qualitative and quantitative changes in the pulmonary compartment of the mononuclear phagocyte system during different periods after surgery. These changes have compensatory and adaptive nature because of loss and subsequent partial recovery of the hepatic compartment of the mononuclear phagocyte system.
Insights
Partial hepatectomy alters lung immune cells, specifically the mononuclear phagocyte system. These pulmonary changes are adaptive responses to liver tissue loss and regeneration after surgery.
Area of Science:
- Immunology
- Hepatology
- Pulmonary Medicine
Background:
- The mononuclear phagocyte system (MPS) is crucial for immune surveillance and tissue homeostasis.
- The liver contains a significant portion of the body's MPS, playing a key role in immune responses.
- Surgical removal of liver tissue (partial hepatectomy) impacts systemic immune functions.
Purpose of the Study:
- To investigate the dynamic changes in the pulmonary mononuclear phagocyte system following partial hepatectomy.
- To understand the compensatory and adaptive roles of lung-resident immune cells after liver loss.
Main Methods:
- Animal models undergoing partial hepatectomy.
- Analysis of pulmonary immune cell populations (e.g., macrophages) at various time points post-surgery.
- Assessment of cellular morphology and quantitative changes.
Main Results:
- Significant qualitative and quantitative alterations observed in the pulmonary mononuclear phagocyte system after partial hepatectomy.
- These pulmonary immune cell changes occur during distinct post-operative periods.
- Evidence suggests these lung-based immune responses are compensatory for the loss of hepatic immune function.
Conclusions:
- Partial hepatectomy induces adaptive immunological changes in the lung's mononuclear phagocyte system.
- The pulmonary MPS plays a compensatory role in response to hepatic tissue loss and regeneration.
- Understanding these systemic immune adaptations is vital for managing patients post-hepatectomy.
