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Homology modeling of GPCRs
John Simms1, Nathan E Hall, Polo H C Lam
1Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Abstract:
Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.
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