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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
Published on: October 25, 2024
Pharmacological modulation of Th17.
Juan B De Sanctis1, Jenny V Garmendia, Dolores Moreno
1Institute of Immunology, Faculty of Medicine, Apartado Postal 50109, Caracas, Venezuela. sanctisj@gmail.com
Recent Patents on Inflammation & Allergy Drug Discovery
|June 13, 2009
Summary
A newly identified T helper 17 (Th17) cell subset drives neutrophil accumulation. Targeting this subset or interleukin-17 (IL-17) signaling offers potential therapeutic strategies for inflammatory diseases.
Area of Science:
- Immunology
- Cell Biology
- Pharmacology
Background:
- A novel subset of T helper 17 (Th17) cells has been identified.
- This Th17 subset is implicated in inducing chemokine and growth factor release.
- It also contributes to neutrophil accumulation in various mammalian organs.
Purpose of the Study:
- To review patents related to the pharmacological targeting of IL-17.
- To explore the therapeutic potential of modulating Th17 cell activity and IL-17 signaling.
Main Methods:
- Patent literature review focusing on IL-17 and Th17 cell modulation.
- Analysis of therapeutic applications suggested by patented interventions.
Main Results:
- Patents cover strategies for both promoting and targeting IL-17.
- These patented approaches aim to address diseases associated with Th17-mediated inflammation.
Conclusions:
- Interleukin-17 (IL-17) and Th17 cell pathways represent significant targets for drug development.
- Pharmacological interventions modulating IL-17 signaling hold promise for treating numerous inflammatory conditions.
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