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Updated: Jun 22, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
Published on: October 25, 2024
Pharmacological modulation of Th17
Juan B De Sanctis1, Jenny V Garmendia, Dolores Moreno
1Institute of Immunology, Faculty of Medicine, Apartado Postal 50109, Caracas, Venezuela. sanctisj@gmail.com
Abstract:
Recently, a third subset of Th17 cells has been described. This T helper subset induces the release of chemokines and growth factors and causes neutrophil accumulation in several mammalian organs. Pharmacological intervention blocking Th17 generation as well as IL-17 signaling might prove useful in a variety of diseases including asthma, chronic obstructive pulmonary disease, Crohn's disease, cystic fibrosis, multiple sclerosis, psoriatic disease and rheumatoid arthritis. Here, we describe the patents that address a potential pharmacological use of promoting or targeting IL-17.
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