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Related Experiment Videos

The Brenner tumor: a clinicopathologic review.

R W Balasa, L L Adcock, K A Prem

    Obstetrics and Gynecology
    |July 1, 1977
    PubMed
    Summary

    Brenner tumors of the ovary, while uncommon, are generally understood to arise from surface epithelium. Variants include proliferating and malignant types, with the latter having a poor prognosis.

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    Area of Science:

    • Gynecologic Pathology
    • Ovarian Neoplasms

    Background:

    • Brenner tumors are rare ovarian neoplasms with a long history of study since 1898.
    • Histogenesis remains a key area of investigation for this uncommon tumor.

    Purpose of the Study:

    • To review the existing literature on Brenner tumors of the ovary.
    • To discuss the histogenesis, clinical presentation, pathologic variants, and associated conditions of Brenner tumors.

    Main Methods:

    • Literature review of clinical and pathologic studies on Brenner tumors.
    • Analysis of reported cases and histopathologic findings.

    Main Results:

    • General agreement exists that Brenner tumors originate from surface (coelomic) epithelium.
    • Most Brenner tumors are asymptomatic; some exhibit estrogen production.
    • Pathologic variants include benign, proliferating, and malignant types, with malignant tumors having a poor prognosis.
    • Approximately 30% of benign Brenner tumors are associated with co-existing serous or mucinous cystadenomas.

    Conclusions:

    • Brenner tumors are of surface epithelial origin.
    • Malignant Brenner tumors are associated with poor outcomes.
    • Co-occurrence with other ovarian neoplasms is noted in a significant percentage of benign cases.

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