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Updated: May 1, 2026

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Published on: October 15, 2009
Intravenous leiomyomatosis with intracardiac extension
Cho-Kai Wu1, Jing-Ling Luo, Chung-Yi Yang
1Department of Internal Medicine, National Taiwan University College of Medicine and Hospital Yun-Lin Branch.
Insights
Intravenous leiomyomatosis is a rare uterine condition extending to the heart. Successful surgical removal offers a curative treatment, even in critical cases of advanced disease.
Area of Science:
- Gynecologic Oncology
- Cardiovascular Surgery
- Pathology
Background:
- Uterine leiomyoma is common, but intravenous leiomyomatosis with intracardiac extension is rare.
- Clinical presentation varies with intracardiac involvement severity.
- Complete surgical resection is the primary treatment modality.
Observation:
- A 39-year-old woman presented with dyspnea and right heart failure.
- Preoperative studies diagnosed leiomyomatosis originating from the uterus, extending into the inferior vena cava and right atrium.
- The patient required resuscitation due to respiratory and severe right heart failure.
Findings:
- Successful two-stage surgical intervention was performed.
- The patient experienced a positive postoperative recovery.
Implications:
- This case highlights an unusual presentation of intravenous leiomyomatosis.
- Curative surgical treatment is feasible even in critically ill patients with advanced disease.
- Demonstrates the importance of multidisciplinary management for rare gynecologic and cardiovascular complications.
Abstract:
Whereas uterine leiomyoma is a common woman disease, intravenous leiomyomatosis with intracaval and intracardiac complications is a rare condition. The initial presentation is dependent upon the severity of the intracardiac involvement, although complete surgery is the best treatment. The case of a 39-year-old woman is described here, with an initial presentation of dyspnea and right heart failure. Leiomyomatosis originating from the uterus and extending to the inferior vena cava and right atrium was diagnosed from various preoperative studies. The patient was resuscitated because of respiratory failure and severe right heart failure. However, she was operated successfully through a two-stage approach and remained well postoperatively. This case illustrates an intriguing presentation of intravenous leiomyomatosis and a curative surgical intervention even in critical condition.
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