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Updated: Jun 22, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Myelopeptide-5 abolishes virus-induced immunosuppression by restoring T cell functions
R G Belyovskaya1, M V Kalyuzhnaya, V P Shevchenko
1The Russian Academy of Sciences, Moscow, Russia. stas@ibch.ru
Abstract:
Myelopeptide-5 (MP-5; synthetic analog of endogenous low-molecular-weight peptide Val-Val-Tyr-Pro-Asp) neutralized the immunosuppressive effects of antiviral vaccines (influenza, measles, and measles/parotitis) and stimulated their immunogenicity by restoring functional activity of T cells, suppressed by the viruses. Specific binding of MP-5 to CD4(+) lymphocyte (its target cell) was studied using [(3)H]MP-5 (dissociation constant 2.03 x 10(-7) M).
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