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Updated: Jun 22, 2026
Operant Procedures for Assessing Behavioral Flexibility in Rats
Published on: February 15, 2015
Effect of tactivin on functional disturbances in avoidance reaction in rats
N M Kiseleva1, A V Novoseletskaya, I V Zimina
1Laboratory of Molecular Immunology, Institute of Physico-Chemical Medicine, Russian Ministry of Health, Moscow, Russia. kiseleva.67@mail.ru
Abstract:
Experiments on outbred albino rats showed that tactivin (thymic polypeptide preparation) reduced functional disturbances in active avoidance reaction induced by extra electric current exposure violating the established relationships between the stimuli, reaction, and its result. The preparation provided high level of avoidance reaction after its violation. New effects of immunocorrective agent tactivin were detected. It not only restored the disordered immunological parameters, but also exhibited a pronounced effect on the higher integrative functions of the brain and produced an antistress effect.
