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Updated: Jun 22, 2026
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Individual human phenotypes in metabolic space and time
Patrizia Bernini1, Ivano Bertini, Claudio Luchinat
1Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino, Italy. bertini@cerm.unifi.it
Journal of Proteome Research
|June 17, 2009
Summary
Individual metabolic phenotypes are remarkably stable over time, influenced by genetics, environment, and the gut microbiome. Understanding these unique metabolic profiles is key for clinical applications.
Area of Science:
- Metabolomics
- Microbiome research
- Personalized medicine
Background:
- Individual phenotypic differences arise from genetic and environmental factors.
- Understanding metabolic phenotypes is crucial for clinical and therapeutic applications.
- Previous evidence for unique individual metabolic phenotypes was limited.
Purpose of the Study:
- To investigate the stability and influencing factors of individual metabolic phenotypes.
- To explore the concept of the metabolic phenotype as a metagenomic entity.
Main Methods:
- Longitudinal analysis of individual phenotypes over years.
- Assessment of host metabolic phenotype influenced by genetics and environment.
- Evaluation of gut microbiome impact on metabolic phenotype.
Main Results:
- Individual metabolic phenotypes demonstrate significant invariance over extended periods.
- The host metabolic phenotype is shaped by both genetic and environmental factors.
- The gut microbiome plays a substantial role in defining the individual metabolic phenotype.
Conclusions:
- Individual metabolic phenotypes are largely stable and predictable over time.
- The metabolic phenotype is a complex metagenomic entity influenced by host genetics, environment, and gut microbiome.
- This understanding can advance personalized clinical and therapeutic strategies.
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