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Doripenem

David L Paterson1, Daryl D Depestel

  • 1The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia. david.antibiotics@gmail.com

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 17, 2009
PubMed

Insights

Doripenem, a new carbapenem antibiotic, shows broad-spectrum activity against many bacteria, including resistant strains. It is approved for intra-abdominal and urinary tract infections, with a low risk of seizures.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Carbapenems are crucial antibiotics for treating severe bacterial infections.
  • Doripenem is a recently developed carbapenem with a distinct antimicrobial profile.

Purpose of the Study:

  • To review the antimicrobial spectrum, clinical applications, and safety profile of doripenem.
  • To identify areas requiring further research regarding doripenem's use.

Main Methods:

  • In vitro susceptibility testing against various bacterial pathogens.
  • Review of clinical trial data for efficacy and safety.
  • Pharmacodynamic considerations, including infusion strategies.

Main Results:

  • Doripenem exhibits potent in vitro activity against Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter species, and Bacteroides fragilis.
  • It demonstrates activity against extended-spectrum beta-lactamase-producing strains but not against methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci.
  • Resistant P. aeruginosa mutants are less readily selected with doripenem compared to other carbapenems. Doripenem has a low propensity to cause seizures.

Conclusions:

  • Doripenem is effective for complicated intra-abdominal and urinary tract infections.
  • Further studies are needed to establish optimal dosing for specific populations (neonatal, pediatric, cystic fibrosis) and renal replacement therapies.
  • The long-term utility of doripenem depends on controlling the spread of carbapenem-resistant organisms.

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