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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: Jun 22, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Photonic-crystal waveguide biosensor.

Nina Skivesen, Amélie Têtu, Martin Kristensen

    Optics Express
    |June 18, 2009
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a photonic-crystal waveguide sensor for sensitive biosensing applications. The device accurately detects low protein concentrations and measures refractive index across a wide range of fluid viscosities.

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    Last Updated: Jun 22, 2026

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    Published on: February 25, 2017

    Area of Science:

    • Photonics
    • Nanotechnology
    • Biomedical Engineering

    Background:

    • Photonic-crystal waveguides offer unique light-confining properties.
    • Biosensors are crucial for detecting biological analytes and monitoring physiological changes.

    Purpose of the Study:

    • To develop and characterize a novel photonic-crystal waveguide sensor for biosensing.
    • To evaluate the sensor's performance in refractive index measurements and protein concentration detection.

    Main Methods:

    • Fabrication of a photonic-crystal waveguide.
    • Application of the waveguide in a sensing setup.
    • Measurement of refractive index changes.
    • Detection of varying protein concentrations.

    Main Results:

    • The sensor achieved excellent signal-to-noise ratio for protein concentrations around 10 µg/ml (0.15 µMolar).
    • A broad dynamic sensing range for refractive index was demonstrated, suitable for diverse fluid types.
    • The sensor showed high sensitivity and a wide operational range.

    Conclusions:

    • The photonic-crystal waveguide sensor is a promising platform for high-sensitivity biosensing.
    • The sensor's broad dynamic range and sensitivity enable versatile applications in biological and chemical sensing.