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Updated: Jun 22, 2026
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation
Raphaël Serduc1, Elke Bräuer-Krisch, Audrey Bouchet
1Université de Toulouse, UPS, Centre de Recherche Cerveau et Cognition, Toulouse, France. raph.serduc@gmail.com
Abstract:
The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.
