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[The expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding]
Li-li Zhou1, Li-na Yang, Li Wang
1The Hospital of Heilongliang Provine, Harbin 150036, China. lily_72_65@chinaren.com.cn
Objective:
To research the expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding.
Methods:
Detecting the expression of Bcl-2 and Bax protein in 40 cases of endometrium tissue of dysfunctional uterine bleeding patients with immunohistochemistry antibiotics protein-peroxide emzyme (SP)methods.
Results:
(1) The expression of Bcl-2 protein changes clearly and periodically in endometrium in normal cycle, the difference is obvious (P < 0.05). (2) The Bcl-2 protein develops with the hyperplasia in endometrium and the expression intensity is enhanced, the difference is obvious( P < 0.05). (3) The expression of Bax gene is masculine in endometrium in normal menstrual cycle. (4) The expression of Bax gene descends gradually with hyperplasia in uterine endometrium (P < 0.05).
Conclusion:
Apoptosis of endometrium cell is restrained from the excessive expression of Bcl-2 protein and deficient expression of Bax protein, so the uterine endometrium gets to hyperplasia or notypical hyperplasia.
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