Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developments in buccal drug delivery.

M E de Vries1, H E Boddé, J C Verhoef

  • 1Division of Pharmaceutical Technology, Leiden State University, The Netherlands.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methodology for Free-Floating Organ Culture of Mid-gestation Maxillary Primordial Tissue.

Methods in molecular biology (Clifton, N.J.)·2021
Same author

Grainyhead-like Transcription Factors in Craniofacial Development.

Journal of dental research·2017
Same author

Thermal stability of mefruside-polyvinylpyrrolidone solid dispersions.

Pharmaceutical research·2013
Same author

Biowaiver monographs for immediate release solid oral dosage forms: lamivudine.

Journal of pharmaceutical sciences·2011
Same author

An in vivo-In vitro study of the use of a human skin equivalent for irritancy screening of fatty acids.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Assessment of the potential irritancy of oleic acid on human skin: Evaluation in vitro and in vivo.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same journal

Unveiling the Potential of Drug Delivery Systems for Tyrosine Kinase Inhibitors in the Treatment of Neovascular Eye Diseases.

Critical reviews in therapeutic drug carrier systems·2026
Same journal

Investigation of Bioinspired Nanocurcumin Composites for Antibacterial Applications.

Critical reviews in therapeutic drug carrier systems·2026
Same journal

Advances in the Preparation of Lipid-Based Nanotechnologies: Expanding the Horizons of Therapeutic Applications.

Critical reviews in therapeutic drug carrier systems·2026
Same journal

Nano Lipid Carriers (NLCs): Potential and Promises in Drug Delivery.

Critical reviews in therapeutic drug carrier systems·2026
Same journal

CpG ODNs: Precision Immunotherapy and Recent Trends in Nano-Enabled Nucleotide Delivery.

Critical reviews in therapeutic drug carrier systems·2026
Same journal

Plant-Based Exosomes: Insights and Therapeutic Applications.

Critical reviews in therapeutic drug carrier systems·2026
See all related articles

The buccal mucosa is a promising route for long-term drug delivery, particularly for peptides. This review covers buccal drug absorption, delivery devices, and methods for enhancing drug permeation.

Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Biomedical Engineering

Background:

  • The oral mucosa, specifically the buccal mucosa, presents significant potential for sustained drug administration.
  • Metabolically unstable drugs, such as peptides, are candidates for buccal delivery due to the protective environment.
  • Existing knowledge on buccal drug absorption and delivery devices is reviewed.

Purpose of the Study:

  • To provide a comprehensive overview of buccal drug absorption and delivery technologies.
  • To discuss the structure and physiology of oral mucosae and interspecies differences in permeability.
  • To explore methods for determining mucosal drug absorption and strategies for enhancement.

Main Methods:

  • Review of existing literature on buccal drug absorption and delivery.

Related Experiment Videos

  • Description of oral mucosa structure, physiology, and permeability.
  • Discussion of in vivo and in vitro methods for assessing mucosal drug absorption.
  • Analysis of absorption pathways, mechanisms, and enhancement techniques.
  • Examination of technological strategies for controlling transbuccal drug absorption.

    • Main Results:

    • Buccal mucosa is suitable for long-term drug delivery, especially for peptides.
    • Interspecies differences in oral mucosa permeability are significant.
    • Mucoadhesive devices and device modulation can control drug absorption.
    • Various methods exist for in vitro and in vivo assessment of buccal drug absorption.

    Conclusions:

    • Buccal drug delivery offers a viable alternative for specific drug classes.
    • Technological advancements in mucoadhesive devices enhance drug permeation and administration.
    • Understanding mucosal physiology is key to optimizing buccal drug delivery systems.