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Intraosseous myofibroma simulating an odontogenic lesion
Denis P Souza1, Caio C S Loureiro, Roberto A G Rejas
1Department of Oral and Maxillofacial Surgery, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Journal of Oral Science
|June 25, 2009
Summary
Intraosseous myofibroma is a rare benign tumor that can mimic other jaw lesions. This case highlights the importance of histopathology and immunohistochemistry for accurate diagnosis and conservative treatment in children.
Area of Science:
- Oral and Maxillofacial Pathology
- Pediatric Oncology
- Skeletal Biology
Background:
- Myofibroma is a rare benign tumor affecting soft tissues, bones, and organs, with limited descriptions in jaw bones.
- Intraosseous myofibromas present diagnostic challenges due to their varied radiographic appearance, often simulating cystic or odontogenic lesions.
Observation:
- A case of intraosseous myofibroma in a 7-year-old girl is presented.
- The lesion in the jaw bone exhibited a well-defined unilocular radiolucent appearance.
- Diagnosis required correlation of clinical, radiographic, histopathologic, and immunohistochemical findings.
Findings:
- Histopathologic examination alone was insufficient for definitive diagnosis.
- Immunohistochemical markers including vimentin, alpha-smooth muscle actin, desmin, and S-100 were crucial for diagnosis.
- Conservative treatment was successfully employed for the intraosseous myofibroma.
Implications:
- Accurate diagnosis of intraosseous myofibroma necessitates a multidisciplinary approach combining imaging and molecular markers.
- Understanding the diagnostic nuances of myofibroma is essential for appropriate management in pediatric patients.
- This case contributes to the limited literature on intraosseous myofibromas in the jaw, emphasizing diagnostic strategies.
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