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Updated: Jun 22, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol
Marcelo Calderón1, Ralph Graeser, Felix Kratz
1Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany.
Abstract:
In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented.
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