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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Malignant priapism and secondary bladder cancer]
Pablo Eguíluz Lumbreras1, Alberto Palacios Hernández, Oscar Heredero Zorzo
1Servicio y Cátedra de Urología, Hospital Clínico Universitario de Salamanca, Salamanca, España. paeglu@hotmail.com
Malignant priapism, a rare condition, occurred due to penile metastasis from transitional cell carcinoma. This indicates advanced bladder cancer and a poor prognosis for patients.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Transitional cell carcinoma is a common malignancy of the urinary tract.
- Priapism is a prolonged erection not associated with sexual stimulation, often painful.
- Malignant priapism is a rare complication of advanced cancers.
Observation:
- A patient with advanced bladder cancer (pT4G3) presented with priapism.
- The priapism was characterized by painful penile erection.
- A biopsy of the corpora cavernosa was performed.
Findings:
- Pathologic diagnosis confirmed penile metastasis of transitional cell carcinoma.
- The priapism was directly caused by the spread of cancer to the penis.
- This represents a rare presentation of metastatic bladder cancer.
Implications:
- Priapism secondary to penile metastasis signifies advanced disease.
- The condition is associated with a poor prognosis.
- Highlights the importance of considering metastatic disease in patients with priapism and a history of cancer.
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