Related Experiment Video
Updated: Jun 22, 2026

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices
Published on: September 20, 2019
[Analgetic property of nonspecific thalamic nuclei]
Abstract:
Neruronal activity evoked by pain impulsation in the specific thalamic nuclei and sensorimotor cortex has been recorded in cat. The following data were obtained. Evoked nociceptive neuronal activity was inhibited by stimulation of the nonspecific thalamic nuclei. An antinociceptive impact of the nonspecific thalamic nuclei on the specific thalamic units was fulfilled by both direct and thalamo-cortico-thalamic pathways. Stimulation of the antinociceptive regions of the nonspecific thalamic nuclei abolished evoked nociceptive activity of the cortical units, elicited by both peripheral noxious stimulus and stimulation of the ventro-postero-medial thalamic nuclei. This indicates that the nonspecific thalamic nuclei inhibit the cortical activity on the thalamic, as well as, on the cortical level.
Related Concept Videos
Diencephalon: Thalamus and Information Relay
Diencephalon: Hypothalamus and Coordination
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Diencephalon: Anatomical Regions
Local Anesthetics: Mechanism of Action
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Antiepileptic Drugs: Glutamate Antagonists

