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Current concepts in lactate exchange.

G A Brooks1

  • 1Department of Physical Education, University of California, Berkeley 94720.

Medicine and Science in Sports and Exercise
|August 1, 1991
PubMed
Summary
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Lactic acid (lactate) is not a waste product but a vital metabolite. Its exchange between cells, blood, and organs allows for coordinated metabolism, especially during exercise.

Area of Science:

  • Metabolic biochemistry
  • Physiology

Background:

  • Lactate was historically considered a metabolic waste product.
  • Recent research highlights lactate's role in intercellular and inter-organ metabolite exchange.

Purpose of the Study:

  • To provide historical context for lactate exchange research.
  • To introduce the "lactate shuttle" hypothesis.
  • To integrate diverse findings on lactate metabolism.

Main Methods:

  • Review of symposium proceedings on lactate exchange.
  • Synthesis of research on lactate uptake/release in skeletal muscle and heart.
  • Analysis of hepatic lactate balance and glycogen synthesis.
  • Examination of lactate transporter properties and modeling.

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Main Results:

  • Lactate formation, exchange, and utilization are temporally and spatially distinct.
  • The "lactate shuttle" hypothesis integrates various metabolic roles of lactate.
  • Corollaries include training effects, beta-adrenergic stimulation, and hypoxia's influence on glycolysis.

Conclusions:

  • Lactate is a key signaling molecule coordinating intermediary metabolism.
  • Understanding lactate exchange is crucial for comprehending whole-body metabolic regulation.
  • Lactate plays a significant role in energy production and substrate utilization across tissues.