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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Related Experiment Video

Updated: Jun 22, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Perioperative anaphylaxis.

P M Mertes1, M Lambert, R M Guéant-Rodriguez

  • 1Service d'Anesthésie-Réanimation Chirurgicale, CHU de Nancy, Hôpital Central, 29 Avenue de Lattre de Tassigny, Nancy Cedex 54035, France. pm.mertes@chu-nancy.fr

Immunology and Allergy Clinics of North America
|July 1, 2009
PubMed
Summary
This summary is machine-generated.

Anesthesia-related anaphylaxis affects 1 in 10,000 to 20,000 patients, often caused by neuromuscular blocking agents. Diagnosis involves tryptase measurements and specific allergy tests.

Related Experiment Videos

Last Updated: Jun 22, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Area of Science:

  • Anesthesiology
  • Immunology
  • Allergy

Background:

  • Anaphylaxis during anesthesia is a rare but serious adverse event.
  • The incidence ranges from 1 in 10,000 to 1 in 20,000 anesthetic procedures.

Purpose of the Study:

  • To review the causes and diagnostic methods for immune-mediated anaphylaxis during anesthesia.

Main Methods:

  • Literature review of anaphylaxis during anesthesia.
  • Analysis of causative agents and diagnostic techniques.

Main Results:

  • Neuromuscular blocking agents are the most common cause, followed by latex and antibiotics.
  • All anesthetic drugs and substances are potential triggers.
  • Diagnosis relies on immediate tryptase measurements, skin tests, and specific IgE or basophil activation assays.

Conclusions:

  • Prompt diagnosis and identification of triggers are crucial for managing anaphylaxis during anesthesia.
  • Understanding common culprits and diagnostic tools aids in patient safety and care.