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Retroperitoneal pararenal Castleman's disease
O P Michail1, P Tsirkinidis, A Androulaki
11st Department of Surgery, University of Athens, School of Medicine, LAIKO Hospital, Athens, Greece. omichail@yahoo.com
The West Indian Medical Journal
|July 2, 2009
Summary
Castleman disease, a rare disorder, can present as a retroperitoneal mass. Early diagnosis and exclusion of lymphoma are crucial for localized Castleman disease management.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Castleman disease is a rare lymphoproliferative disorder.
- It can manifest as a solitary mass, mimicking other retroperitoneal tumors.
Observation:
- A 51-year-old male presented with flank pain and a large retroperitoneal mass.
- Imaging revealed a hypervascular, heterogeneous mass, leading to differential diagnoses including lymphoma, sarcoma, or vascular tumor.
Findings:
- Histopathology confirmed hyaline Castleman disease, a unicentric variant.
- Extensive work-up, including HIV/HHV-8 testing, bone marrow studies, and serum protein electrophoresis, ruled out multicentric disease and lymphoma.
Implications:
- Castleman disease should be considered in the differential diagnosis of hypervascular retroperitoneal masses.
- Thorough investigation is essential to differentiate unicentric from multicentric forms and exclude concurrent lymphoma.
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