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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Neuromyelitis optica with HTLV-1 infection: different from acute progressive HAM?
Michiaki Koga1, Toshiyuki Takahashi, Motoharu Kawai
1Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube. kogamrk@yamaguchi-u.ac.jp
Abstract:
Acute variant of human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) has been postulated as termed "acute HAM" or "rapidly progressive HAM". However, it remains controversial whether HAM itself could cause such rapid progression. We report a patient with HTLV-1 infection, in whom the diagnosis of neuromyelitis optica (NMO) could be made based on relapsing-remitting course of opticospinal disturbance and positive anti-aquaporin-4 (AQP4) antibody. Careful testing of anti-AQP4 antibody is necessary to establish whether or not acute HAM is a clinical variant of HAM.
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