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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

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Local complement activation in nasal polyposis.

Thibaut Van Zele¹, Frauke Coppieters, Philippe Gevaert

¹Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium. thibaut.vanzele@ugent.be

The Laryngoscope

|July 3, 2009

Summary

This summary is machine-generated.

The complement system is activated in nasal secretions of patients with chronic rhinosinusitis with nasal polyps (CRSwNP), correlating with inflammation. This suggests its role in CRSwNP pathogenesis, contributing to edema and granulocytic inflammation.

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Area of Science:

Immunology
Otorhinolaryngology

Background:

Chronic rhinosinusitis with nasal polyps (CRSwNP) pathogenesis is not fully understood.
Bacterial colonization in CRSwNP suggests a role for innate immune mechanisms like the complement system.
Previous studies have limited investigation into the complement system's role in CRSwNP.

Purpose of the Study:

To investigate local and systemic complement system activation in CRSwNP.
To correlate complement activation with local/systemic eosinophilic and neutrophilic inflammation.
To assess the relationship between complement activation and local plasma exudation in CRSwNP.

Main Methods:

Quantified complement factors (C3a desArg, C5a desArg) and inflammatory markers (eosinophilic cationic protein, myeloperoxidase) in nasal secretions and serum.
Analyzed albumin and alpha2-macroglobulin for plasma exudation.
Used immunohistochemistry to detect the membrane attack complex (C5b9) in nasal tissue.

Main Results:

Significantly higher C3a desArg and C5a desArg concentrations were found in CRSwNP nasal secretions compared to controls.
Serum complement factor levels did not differ significantly between CRSwNP patients and controls.
C5a desArg in secretions correlated with eosinophil cationic protein, and C5b9 was deposited in CRSwNP nasal polyp tissue.

Conclusions:

The complement system is locally activated in CRSwNP.
Complement activation correlates with eosinophilic inflammation and plasma exudation in CRSwNP.
These findings support the complement system's involvement in CRSwNP pathogenesis, contributing to edema and inflammation.