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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Skin Cancer

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Burn Injuries

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Staphylococcal Skin Infections

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Updated: Jun 21, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Blistering skin conditions.

Belinda Welsh¹

¹St Vincent's Hospital, Melbourne and Sunbury Dermatology and Skin Cancer Clinic, Sunbury, Victoria. drbwelsh@bigpond.net.au

Australian Family Physician

|July 4, 2009

Summary

This summary is machine-generated.

Blistering skin conditions have diverse causes, including infections, autoimmune disorders, and metabolic diseases. Accurate diagnosis often requires biopsy for histopathology and immunofluorescence, with early dermatologist referral crucial for managing these challenging conditions.

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Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

Area of Science:

Dermatology
Pathology

Background:

Blistering skin conditions present with varied etiologies.
Blister pattern and distribution aid diagnosis, but biopsy is typically needed for definitive histopathology and immunofluorescence.

Purpose of the Study:

To review the clinical and pathological features of blistering skin conditions.
Focus on bullous impetigo, dermatitis herpetiformis, bullous pemphigoid, and porphyria cutanea tarda.

Main Methods:

Literature review of blistering skin conditions.
Analysis of clinical and pathological presentations.
Emphasis on diagnostic techniques including biopsy, histopathology, and immunofluorescence.

Main Results:

Infections, contact reactions, and drug eruptions are common causes of blistering.
Porphyria cutanea tarda represents a metabolic cause of blistering.
Autoimmune blistering diseases, though rare, can lead to significant morbidity and mortality if untreated.

Conclusions:

Differential diagnosis should include infections, contact reactions, and drug eruptions.
Metabolic diseases like porphyria can manifest as blistering skin conditions.
Awareness of autoimmune blistering diseases is critical due to potential for severe outcomes; early dermatological consultation is recommended for challenging cases.