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Updated: Jun 21, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Diffuse large B-cell lymphomas and burkitt lymphoma.

Laurence de Leval¹, Robert Paul Hasserjian

¹Department of Pathology, CHU Sart Tilman, Institute of Pathology, Liège, Belgium. l.deleval@ulg.ac.be

Hematology/Oncology Clinics of North America

|July 7, 2009

Summary

This summary is machine-generated.

Recent advances in aggressive lymphomas, including diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), are summarized. The article highlights new classifications and diagnostic challenges for borderline high-grade B-cell neoplasms.

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Last Updated: Jun 21, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Area of Science:

Hematology
Oncology
Pathology

Background:

Diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphoma (BL) are the most common aggressive lymphomas.
DLBCLs are biologically heterogeneous, while BL is genetically homogeneous but clinicopathologically variable.
Existing classifications require updates to reflect new understanding of these neoplasms.

Purpose of the Study:

To summarize recent advances in DLBCL and BL, adhering to the latest World Health Organization (WHO) classification.
To focus on changes and new additions since the previous WHO classification.
To discuss diagnostic and therapeutic challenges, particularly for neoplasms with intermediate features.

Main Methods:

Review of recent scientific literature and clinical studies.
Analysis of updated diagnostic criteria based on the latest WHO classification.
Discussion of challenging cases and emerging research findings.

Main Results:

The latest WHO classification introduces new variants and subgroups of DLBCLs.
New "borderline" categories are defined for high-grade B-cell neoplasms with intermediate features.
Specific focus on neoplasms with features intermediate between DLBCL and BL is presented.

Conclusions:

The updated WHO classification refines the understanding of aggressive B-cell lymphomas.
Diagnostic and therapeutic strategies need to adapt to new classifications, especially for intermediate-grade neoplasms.
Further research is needed to address the challenges posed by borderline categories.