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Intrasinusoidal ALK-positive anaplastic large cell lymphoma.

Eilena Braye1, Laurence de Leval2

  • 1Promed Laboratoire SA, Department of Pathology, Marly, Switzerland.

Journal of Hematopathology
|December 9, 2025
PubMed
Summary
This summary is machine-generated.

Anaplastic large cell lymphoma (ALCL) with exclusive intrasinusoidal infiltration is rare. This presentation mimics metastatic carcinoma but requires prompt recognition for effective treatment of ALK-positive ALCL.

Keywords:
ALCLALK positiv ALCLAnaplastic large cell lymphomaT cell lymphoma

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Area of Science:

  • Hematopathology
  • Oncology
  • Lymphoma Research

Background:

  • Anaplastic large cell lymphoma (ALCL), particularly ALK-positive subtypes, can involve lymph node sinuses.
  • Exclusive intrasinusoidal infiltration of lymph nodes by ALCL is an exceptionally rare presentation.

Purpose of the Study:

  • To describe a unique case of ALK-positive ALCL presenting with isolated intrasinusoidal infiltration of an inguinal lymph node.
  • To highlight the diagnostic challenges posed by this rare pattern, which can mimic metastatic carcinoma.
  • To emphasize the importance of recognizing this presentation for appropriate management.

Main Methods:

  • Case report of a 39-year-old woman with stage I inguinal lymphadenopathy.
  • Histopathological examination of the lymph node, including immunohistochemistry for CD30 and ALK.
  • Clinical correlation and diagnostic workup.

Main Results:

  • Massive intrasinusoidal infiltration by CD30- and ALK-positive atypical cells was observed.
  • Lymph node architecture was preserved despite extensive infiltration.
  • The pattern mimicked metastatic carcinoma, posing a diagnostic challenge.

Conclusions:

  • Exclusive intrasinusoidal infiltration by ALK-positive ALCL is a rare but critical differential diagnosis in cases of lymphadenopathy.
  • Prompt recognition is essential as ALK-positive ALCL generally responds well to therapy.
  • Further research is needed to elucidate the clinical and prognostic significance of this specific presentation.