Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A genetic risk score based on BCL11A and HBS1L-MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients.

British journal of haematology·2026
Same author

Editorial: Unraveling inflammatory pathways in sickle cell disease: molecular, cellular and translational insights.

Frontiers in immunology·2026
Same author

Anti-IL-18 immunotherapy decreases inflammatory and vaso-occlusive responses in mice with sickle cell disease.

Experimental hematology·2026
Same author

Vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D levels: association with cerebrovascular disease in sickle cell anemia.

Pediatric hematology and oncology·2025
Same author

Caspase-1 activation drives vascular inflammatory processes and hypoperfusion in intravascular hemolysis.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Circulating Monocytes Contribute to Erythrocyte Clearance in Polycythemia Vera.

International journal of molecular sciences·2025
Same journal

Evaluation of hemoglobin interference thresholds for chemical urinalysis panels.

Clinical biochemistry·2026
Same journal

Integrated genomic and biochemical diagnosis of a novel homozygous start-loss variant in AKR1D1 associated with neonatal cholestasis.

Clinical biochemistry·2026
Same journal

Agreement between POC glucose meters and blood gas analyzers varies across ICU patient populations.

Clinical biochemistry·2026
Same journal

From variability to value: Advancing vancomycin therapeutic drug monitoring toward decision-grade practice through commutability-informed external quality assessment and uncertainty-aware reporting.

Clinical biochemistry·2026
Same journal

Response to the letter to the editor: From variability to value: Advancing vancomycin therapeutic drug monitoring toward decision-grade practice through commutability-informed external quality assessment and uncertainty-aware reporting.

Clinical biochemistry·2026
Same journal

What are the correlates of laboratory productivity in clinical laboratories in the Asia Pacific region?

Clinical biochemistry·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Hemoglobin disorders and endothelial cell interactions.

Nicola Conran1, Fernando F Costa

  • 1Hematology and Hemotherapy Centre, School of Medical Sciences, University of Campinas - UNICAMP, Brazil. conran@unicamp.br

Clinical Biochemistry
|July 8, 2009
PubMed
Summary
This summary is machine-generated.

Endothelial damage and inflammation are key to sickle cell disease (SCD) and beta-thalassemia. Targeting endothelial dysfunction offers a promising therapeutic strategy for these hemoglobinopathies.

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Related Experiment Videos

Last Updated: Jun 21, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Area of Science:

  • Vascular biology and hematology
  • Pathophysiology of hemoglobinopathies

Background:

  • Endothelial damage and inflammation are central to sickle cell disease (SCD) and beta-thalassemia syndromes.
  • Endothelial dysfunction contributes to pulmonary hypertension and vasculopathy in hemoglobinopathies.
  • Endothelial activation, cell adhesion, inflammation, and oxidative stress drive vaso-occlusion in SCD.

Purpose of the Study:

  • To elucidate the role of the endothelium in the pathophysiology of SCD and beta-thalassemia.
  • To examine the influence of genetic modifiers on endothelial interactions.
  • To assess the impact of hydroxyurea therapy on endothelial function in these diseases.

Main Methods:

  • Review of existing literature on endothelial involvement in SCD and beta-thalassemia.
  • Analysis of the mechanisms linking endothelial dysfunction to disease progression.
  • Discussion of therapeutic strategies targeting endothelial pathways.

Main Results:

  • The endothelium plays a critical role in the inflammatory and vaso-occlusive processes of SCD.
  • Endothelial dysfunction is a common feature in hemoglobinopathies, contributing to complications like pulmonary hypertension.
  • Genetic factors and hydroxyurea therapy can modulate endothelial interactions.

Conclusions:

  • The endothelium is a crucial therapeutic target for managing SCD and beta-thalassemia.
  • Interventions aimed at endothelial pathways hold promise for treating these hematologic disorders.
  • Further research into endothelial interactions may reveal novel treatment strategies.