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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

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Published on: March 24, 2023

Unusual patterns in contact dermatitis: medicaments.

Mark D P Davis¹

¹Department of Dermatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. davis.mark2@mayo.edu

Dermatologic Clinics

|July 8, 2009

Summary

Allergic contact dermatitis from topical medications is common, affecting areas like the scalp and face. Patch testing should include patient-used medicaments to identify allergens.

Area of Science:

Dermatology
Allergology
Pharmacology

Background:

Allergic contact dermatitis (ACD) to topical medicaments is a frequent clinical issue.
Various common topical medications are implicated, including antibiotics, corticosteroids, and anesthetics.

Purpose of the Study:

To highlight the prevalence and common culprits of allergic contact dermatitis from topical medications.
To emphasize the importance of including patient-used medicaments in patch testing protocols.

Main Methods:

Review of common topical medicaments causing ACD.
Identification of susceptible body sites for topical medicament-induced ACD.

Main Results:

Frequent occurrence of ACD linked to topical drug application.

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Key drug classes associated with ACD: antibiotics, antihistamines, NSAIDs, anesthetics, and corticosteroids.

Susceptible body sites include scalp, face, anogenital area, and lower extremities.

Conclusions:

Topical medicaments are a significant cause of allergic contact dermatitis.
Diagnostic patch testing should incorporate the patient's own topical medications.
Awareness of susceptible body sites aids in diagnosis and management.