Related Experiment Video
Updated: Jun 21, 2026

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
Published on: December 20, 2016
Application of ionic liquids in high performance reversed-phase chromatography
Ye Wang1, Minglei Tian1, Wentao Bi1
1Department of Chemical Engineering, Inha University, Incheon 402-751, Korea.
Ionic liquids, or ILs, are versatile "green" chemicals explored as novel additives and stationary phases in chromatography. This review highlights their properties and potential in reversed-phase high-performance liquid chromatography (RP-HPLC).
Area of Science:
- Analytical Chemistry
- Green Chemistry
Background:
- Ionic liquids (ILs) are recognized for their unique properties and environmental benefits.
- They are increasingly utilized in various analytical chemistry applications.
- Recent research explores ILs as novel separation media.
Purpose of the Study:
- To review the properties and mechanisms of ionic liquids.
- To explore their potential applications in reversed-phase high-performance liquid chromatography (RP-HPLC).
- To evaluate ILs as mobile phase modifiers and surface-bonded stationary phases.
Main Methods:
- Literature review focusing on ionic liquids in chromatography.
- Analysis of IL properties and mechanisms relevant to separation science.
- Examination of applications in RP-HPLC, including mobile phase modification and stationary phase synthesis.
Main Results:
- Ionic liquids exhibit unique physicochemical properties beneficial for chromatographic separations.
- They can be effectively used as mobile phase additives to enhance separation.
- Novel stationary phases can be synthesized by combining ILs with silica.
Conclusions:
- Ionic liquids offer significant advantages and potential in the field of chromatography.
- Their application as mobile phase modifiers and surface-bonded stationary phases in RP-HPLC is promising.
- ILs represent a valuable tool for advancing analytical separation techniques.
Related Concept Videos
High-Performance Liquid Chromatography: Introduction
In HPLC, two phases play a critical role in the separation process:
High-Performance Liquid Chromatography: Elution Process
Ion-Exchange Chromatography
High-Performance Liquid Chromatography: Instrumentation
Supercritical Fluid Chromatography
SFC utilizes a supercritical fluid mobile phase,...
Gas Chromatography: Types of Columns and Stationary Phases
For an analyte to remain on the column for a sufficient amount of time, it must exhibit some level of compatibility (or...

