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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...

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Governing stem cell banks and registries: emerging issues.

Rosario M Isasi1, Bartha M Knoppers

  • 1Centre de Recherche en Droit Public, Université de Montréal, C.P. 6128 succ. Centre-ville, Montréal, QC H3C 3J7, Canada. rosario.isasi@umontreal.ca

Stem Cell Research
|July 10, 2009
PubMed
Summary
This summary is machine-generated.

Stem cell banks and registries are crucial for accessing quality-controlled, ethically sourced stem cell lines globally. This study surveys international stem cell banking initiatives to analyze policies and governance, identifying key challenges in provenance, access, and deposit.

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Area of Science:

  • Biomedical Research
  • Stem Cell Biology
  • Biobanking

Background:

  • Growing national and international stem cell research necessitates robust stem cell banking infrastructure.
  • Stem cell banks and registries are vital for transnational access to quality-controlled and ethically sourced stem cell lines.
  • Existing stem cell policies range from restrictive to liberal, influencing banking practices.

Purpose of the Study:

  • To report preliminary findings from a survey of stem cell banks within the International Stem Cell Banking Initiative (ISCBI).
  • To analyze national policies and governance approaches in international human embryonic stem cell (hESC) banking.
  • To identify areas of convergence and variance in hESC banking policies and governance.

Main Methods:

  • Survey of stem cell banks participating in the International Stem Cell Banking Initiative (ISCBI).
  • Questionnaire addressing research policies (e.g., human embryonic stem cell research permissibility) and stem cell banking governance.
  • Complementary scholarly research by the authors.

Main Results:

  • Overview of the current international human embryonic stem cell (hESC) banking landscape.
  • Analysis of national policy and governance approaches in surveyed stem cell banks.
  • Identification of convergence and variance in international hESC banking practices.

Conclusions:

  • The study provides a starting point for discussing key issues in hESC line provenance, access, and deposit.
  • Findings encourage further research into the banking and governance of various stem cell sources beyond research-grade hESCs.
  • Highlights the essential role of stem cell banks and registries in advancing global stem cell research.