Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Jiedu Huoxue decoction inhibits cardiomyocyte apoptosis via PTEN/AKT/GSK3β-mediated mitochondrial dynamics in myocardial infarction: an integrative study of network pharmacology, transcriptomics and molecular docking.

Chinese medicine·2026

Same author

Longitudinal Association of Physical-Psychological-Cognitive Multimorbidity With Health Care Utilization and Costs Among Middle-Aged and Older People in China.

Asia-Pacific journal of public health·2026

Same author

Injectable Thermosensitive Placental ECM-Copper Hydrogel With Endothelial Progenitor Cells for Pressure Ulcer Repair.

Journal of biomedical materials research. Part B, Applied biomaterials·2026

Same author

Advanced extracellular vesicle therapeutics: From molecular engineering to intelligent devices.

Acta biomaterialia·2026

Same author

Biomimetic hydrogels integrated with strontium and zinc co-substituted mesoporous silica nanoparticles with osteo-immunomodulatory and osteo-angiogenic functions for advanced bone regeneration.

Biomaterials advances·2026

Same author

3D-printed functional engineered intestinal models.

Journal of materials chemistry. B·2026

Same journal

Spatially distributed carbon quantum dots in TiO<sub>2</sub> for photothermal-assisted hydrogen production from seawater.

Chemical communications (Cambridge, England)·2026

Same journal

Ultrasonication-assisted preparation of Li<sub>3</sub>PS<sub>4</sub> suspension for all-solid-state Li-ion batteries.

Chemical communications (Cambridge, England)·2026

Same journal

Dual-active-site engineering in cobalt-porphyrin porous hyper-crosslinked polymers enables synergistic catalysis for CO<sub>2</sub> cycloaddition with epoxides.

Chemical communications (Cambridge, England)·2026

Same journal

Optimizing nickel and cobalt-based water oxidation electrocatalysts <i>via</i> iron post-modification.

Chemical communications (Cambridge, England)·2026

Same journal

Facile preparation of a dual-readout metal-organic framework with aggregation-induced emission for highly sensitive detection of GST-α and Fe<sup>2</sup>.

Chemical communications (Cambridge, England)·2026

Same journal

Plasma-assisted ammonia synthesis utilizing water as a hydrogen source: progress, challenges, and prospects.

Chemical communications (Cambridge, England)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

High-resolution cross-reactive array for alkaloids.

Renjun Pei¹, Aihua Shen, Mark J Olah

¹Division of Experimental Therapeutics, Department of Medicine, Columbia University, New York, NY 10032, USA.

Chemical Communications (Cambridge, England)

|July 10, 2009

Summary

This summary is machine-generated.

Researchers developed a high-resolution DNA array to classify alkaloids. This novel cross-reactive array can identify various alkaloid structures across different concentrations.

More Related Videos

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

Related Experiment Videos

Last Updated: Jun 21, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

Area of Science:

Biochemistry
Molecular Biology
Analytical Chemistry

Background:

Alkaloids are a diverse class of nitrogen-containing natural products with significant biological activity.
Accurate and high-resolution classification of alkaloids is crucial for pharmaceutical and chemical research.
Existing methods may lack the specificity or sensitivity required for complex alkaloid mixtures.

Purpose of the Study:

To develop a high-resolution cross-reactive array for classifying alkaloids.
To enable the classification of alkaloids over a range of concentrations.
To create a versatile tool for alkaloid analysis.

Main Methods:

Systematic introduction of a nitroindole analog into a DNA three-way junction.
Design of a hydrophobic pocket within the DNA structure.
Matching structural motifs of the DNA array to alkaloid analytes.

Main Results:

Generation of a high-resolution cross-reactive array.
Successful classification of alkaloids over a range of concentrations.
Demonstration of the array's ability to match structural motifs.

Conclusions:

The developed DNA-based array offers a novel approach for high-resolution alkaloid classification.
This method provides a sensitive and specific platform for analyzing alkaloid compounds.
The strategy of tailoring DNA structures for analyte recognition can be applied to other molecular targets.