Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

G-quadruplex is critical to epigenetic activation of the lncRNA HOTAIR in cancer cells.

iScience·2023
Same author

Heteromeric guanosine (G)-quadruplex derived antenna modules with directional energy transfer.

Nanoscale·2023
Same author

Correction to: A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming.

Oncogene·2023
Same author

A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming.

Oncogene·2022
Same author

DNA Strand Displacement Driven by Host-Guest Interactions.

Journal of the American Chemical Society·2022
Same author

Structure/Function Analysis of Truncated Amino-Terminal ACE2 Peptide Analogs That Bind to SARS-CoV-2 Spike Glycoprotein.

Molecules (Basel, Switzerland)·2022
Same journal

Direct air capture technologies: innovations, integration, and pathways to scale.

Chemical Society reviews·2026
Same journal

Fluorescent merocyanines: from fundamental properties to applications as molecular probes, in bioimaging and as emissive dye aggregates.

Chemical Society reviews·2026
Same journal

Direct impure water electrolysis at industrial scale.

Chemical Society reviews·2026
Same journal

Catalytic valorization of polyolefins: from catalysts and processes to reactors.

Chemical Society reviews·2026
Same journal

Designing stable π-radicals.

Chemical Society reviews·2026
Same journal

Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.

Chemical Society reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
09:02

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization

Published on: July 9, 2015

Base-pairing mediated non-covalent polymers.

Maher Fathalla1, Candace M Lawrence, Nan Zhang

  • 1Department of Chemistry, Tulane University, 2015 Percival Stern Hall, Louisiana 70118, USA.

Chemical Society Reviews
|July 10, 2009
PubMed
Summary
This summary is machine-generated.

Nucleobase interactions form synthetic polymers and aggregates. Guanine analogues and nucleobase derivatives create structured, bioinspired materials responsive to environmental changes.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

Related Experiment Videos

Last Updated: Jun 21, 2026

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
09:02

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization

Published on: July 9, 2015

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

Area of Science:

  • Supramolecular Chemistry
  • Polymer Science
  • Materials Science

Background:

  • Nucleic acid bases (nucleobases) like adenine, guanine, cytosine, and thymine (uracil) are fundamental for DNA/RNA structure via Watson-Crick pairing.
  • Beyond canonical pairing, nucleobases form diverse structures like Hoogsteen and wobble base pairs, and homodimers.

Purpose of the Study:

  • To review the application of nucleobase interactions in creating synthetic polymeric and oligomeric ensembles.
  • To highlight synthetic guanine analogues for higher-order aggregate formation.
  • To discuss de novo polymers with modulated properties via incorporated nucleobase derivatives.

Main Methods:

  • Summarizing literature on synthetic ensembles utilizing nucleobase interactions.
  • Focusing on synthetic analogues of guanine for aggregate stabilization.
  • Examining de novo polymers with appended or integrated nucleobase moieties.

Main Results:

  • Nucleobase-nucleobase interactions are key to the chemistry and structural morphology of synthetic ensembles.
  • Synthetic guanine analogues facilitate the formation of well-defined higher-order aggregates.
  • Incorporation of nucleobase derivatives into polymer backbones modulates material properties.

Conclusions:

  • Nucleobase interactions are versatile tools for constructing synthetic polymers and aggregates.
  • These interactions enable the design of bioinspired materials with environmentally responsive characteristics.
  • The study provides a foundation for developing advanced materials through precise control of nucleobase assembly.