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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jun 21, 2026

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

Whole-genome microarrays: applications and technical issues.

Brian D Gregory¹, Dmitry A Belostotsky

¹Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|July 10, 2009

Summary

This summary is machine-generated.

Tiling DNA microarrays offer comprehensive whole-genome analysis in plant biology. These advanced tools enable diverse applications, including genetic variation studies and epigenetic analyses.

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Last Updated: Jun 21, 2026

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

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Area of Science:

Plant Biology
Genomics
Molecular Biology

Background:

DNA microarrays are established tools in plant biology research.
Technological advancements have led to the development of whole-genome tiling DNA microarrays.

Purpose of the Study:

To summarize the diverse applications of tiling DNA microarrays in plant biology.
To discuss technical and strategic considerations for using tiling microarrays.

Main Methods:

Whole-genome tiling DNA microarray technology.
Review of existing literature and applications.

Main Results:

Tiling microarrays facilitate broad applications in genetic variation studies.
Applications extend to DNA-binding proteins, DNA methylation, and chromatin dynamics.
Transcriptome dynamics can also be investigated using these arrays.

Conclusions:

Tiling DNA microarrays are versatile tools for comprehensive plant genome analysis.
Effective utilization requires understanding specific technical and strategic aspects.