Related Experiment Video
Updated: Jun 21, 2026
06:10
Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion
Published on: June 28, 2024
Validation of continuous cardiac output technologies: consensus still awaited.
Maurizio Cecconi1, Andrew Rhodes
1Department of General Intensive Care, St George's Hospital, Tooting, London SW17 0QT, UK. mauriziocecconi@hotmail.com
Critical Care (London, England)
|July 14, 2009
Summary
Continuous, non-invasive cardiac output monitoring is crucial for intensive care. Standardized validation principles are needed to fairly assess new technologies and compare them with existing methods.
Area of Science:
- Critical care medicine
- Biomedical engineering
- Clinical monitoring
Background:
- Continuous, non-invasive cardiac output (CO) measurement is highly desired in intensive care.
- Current technologies claim to provide this capability, but validation study designs are complex.
- Lack of standardized validation principles hinders fair assessment of new CO monitoring devices.
Discussion:
- The design of validation studies for non-invasive CO monitors requires careful consideration.
- Establishing agreed-upon principles is essential for scientific rigor.
- This will ensure new technologies are evaluated consistently and compared effectively.
Key Insights:
- Standardized validation protocols are necessary for new non-invasive cardiac output technologies.
- Clear principles will enable robust assessment and comparison of monitoring devices.
- Ensuring fair evaluation is paramount for advancing critical care technology.
Outlook:
- Development of consensus guidelines for validation studies.
- Improved methods for assessing the accuracy and reliability of CO monitors.
- Facilitation of evidence-based selection of monitoring technologies in clinical practice.
Related Concept Videos
01:11Cardiac Output and Stroke Volume
Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac output averages...
In an average resting adult male, the typical cardiac output averages...
01:30Pulse rhythm
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
01:26Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
01:19Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
01:17Exercise and Cardiac Output
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...
Sustained exercise increases the muscles' oxygen demand, which can be met...