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Metabonomics: a useful tool for the future surgeon
Paul Goldsmith1, Hayley Fenton, Gareth Morris-Stiff
1Hepatopancreatobiliary and Transplant Unit, St. James's University Hospital, Leeds, United Kingdom. goldsmithpaul@hotmail.com
The Journal of Surgical Research
|July 14, 2009
Summary
Metabonomics, the study of the metabolic profile, offers a powerful new tool for understanding disease. This technology holds significant promise for biomarker and drug development in medicine.
Area of Science:
- Biochemistry
- Systems Biology
- Clinical Diagnostics
Background:
- Recent advancements in
- omics
- technologies (genomics, transcriptomics, proteomics) have enhanced disease understanding.
- Metabonomics, the analysis of the metabolome, provides insights into the end points of biological processes.
Purpose of the Study:
- To review the evolution and applications of metabonomics.
- To highlight the clinical impact and potential of metabonomics.
- To emphasize metabonomics' role in biomarker and drug development.
Main Methods:
- Metabolome analysis utilizes various biological fluids and tissue types.
- Key technology platforms include mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.
Main Results:
- Metabonomics shows promise in toxicology and disease biomarker discovery.
- Applications include studies of renal and hepatic transplants.
- The technology is still developing but demonstrates significant potential.
Conclusions:
- Metabonomics serves as a platform for advancing biomarker and drug development.
- It offers significant potential for future applications in medicine.
- Further research is warranted to fully realize its clinical impact.