Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of diagnostic algorithm for Cushing's syndrome: a tertiary centre experience.

Journal of endocrinological investigation·2024
Same author

[Measuring the emergency psychiatric units activity: An experimental application of the Delphi Method].

L'Encephale·2022
Same author

[Validation of a French version of the 16-item Prodromal Questionnaire (fPQ16) in adolescents and young adults seeking help].

L'Encephale·2021
Same author

[Management of cardiovascular co-morbidities in young patients with early onset psychosis: State of the art and therapeutic perspectives].

L'Encephale·2020
Same author

[Health professionals facing the coronavirus disease 2019 (COVID-19) pandemic: What are the mental health risks?]

L'Encephale·2020
Same author

[Clozapine prescription in the wake of the coronavirus (SARS CoV-2) outbreak: What measures? Why?]

L'Encephale·2020
Same journal

[Artificial Intelligence in the Pharmaceutical Industry: Governance, Quality, and Regulatory Challenges].

Annales pharmaceutiques francaises·2026
Same journal

No evidence of significant natural environmental exposure to arsenic for Napoleon I on the island of Saint Helena (1815-1821).

Annales pharmaceutiques francaises·2026
Same journal

EFFECTS OF GLP-1 RECEPTOR AGONISTS ON PERIODONTAL TISSUE: AN INTERDISCIPLINARY EVIDENCE MAPPING - SCOPING REVIEW.

Annales pharmaceutiques francaises·2026
Same journal

Regulatory non-compliance of parallel imported medicines in Kenya and implications for public health: Evidence from Nairobi County.

Annales pharmaceutiques francaises·2026
Same journal

Prostaglandin analogues in cosmetic products formulated for eyelash lengthening.

Annales pharmaceutiques francaises·2026
Same journal

Mechanistic and thermodynamic evaluation of sodium citrate-mediated hydrotropism for the biopharmaceutical optimization of BCS Class II drug atorvastatin calcium.

Annales pharmaceutiques francaises·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

[Schizophrenia, a neurodevelopmental illness].

J-P Olié1, F Mouaffak, M-O Krebs

  • 1Inserm U894, Center of Psychiatry and Neurosciences, Paris, France. jp.olie@ch-sainte-anne.fr

Annales Pharmaceutiques Francaises
|July 15, 2009
PubMed
Summary
This summary is machine-generated.

Schizophrenia risk is linked to developmental anomalies like low birth weight and cognitive deficits. Genetic and chromosomal factors also suggest neurodevelopmental origins for this psychiatric disorder.

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Related Experiment Videos

Last Updated: Jun 21, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Developmental anomalies are recognized risk factors for schizophrenia.
  • Cognitive deficits and neurological soft signs indicate the schizophrenic spectrum.
  • Neuroimaging reveals structural abnormalities present early in schizophrenia.

Purpose of the Study:

  • To explore the neurodevelopmental origins of schizophrenia.
  • To identify genetic and chromosomal factors contributing to schizophrenia risk.
  • To understand the role of early developmental processes in schizophrenia.

Main Methods:

  • Review of literature on developmental anomalies and schizophrenia.
  • Analysis of neuroimaging findings in schizophrenia patients.
  • Examination of genetic associations, including DISC-1 and neuroregulin-1.
  • Investigation of chromosomal anomalies in schizophrenia cohorts.

Main Results:

  • Low birth weight, congenital malformations, and delayed learning are risk factors.
  • Structural brain abnormalities are evident early in schizophrenia, potentially due to exaggerated development.
  • Specific genes (DISC-1, neuroregulin-1) and chromosomal anomalies are associated with schizophrenia.
  • Early-onset schizophrenia shows a higher prevalence of chromosomal anomalies.

Conclusions:

  • Schizophrenia has significant neurodevelopmental underpinnings.
  • Genetic and environmental factors interact during development to increase risk.
  • Identifying vulnerable phenotypes is crucial for early screening and intervention.