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Increase of beta-actin mRNA upon hypotonic perfusion of perfused rat liver
W A Schulz1, P Eickelmann, C Hallbrucker
1Institut für Physiologische Chemie I, Heinrich Heine Universität, Düsseldorf, Germany.
FEBS Letters
|November 4, 1991
Abstract:
beta-Actin mRNA levels in livers exposed to hypotonic perfusion (from 305 to 225 mosmol/l) for one hour are increased 2-fold relative to albumin mRNA. Like albumin, glyceraldehyde-3-phosphate dehydrogenase and tyrosine aminotransferase mRNAs remain at the levels observed under normotonic conditions. The increase in beta-actin mRNA is interpreted as a cytoskeletal response due to cell swelling.